• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    This document discloses a method to adjust, customize, an accommodating intraocular lens construction for properties of the ciliary mass of the eye. The lens construction includes at least one variable lens component providing variable optical power and at least one haptic component to transfer of movement from the ciliary mass of the eye to the variable lens. The method is provides adjustment, customization, of the lens construction such as adjustment of steepness of accommodative power, or, adjustment of linearity of the accommodative response, or, the elastic properties of the haptic component to optimize the accommodative properties of the lens construction for the individual eye.
    公开号:NL2027718A
    申请号:NL2027718
    申请日:2021-03-08
    公开日:2021-10-20
    发明作者:Pieter Van Lawick Willem；Christiaan Rombach Michiel
    申请人:Akkolens Int B V；
    IPC主号:
    专利说明:

    Method to customize accommodating intraocular lens Introduction Accommodative intraocular lenses restore accommodation of the human eye, meaning, provide the retina with a sharp focus at any object distance, from far to reading distance, by translation of the focus the incoming light beam along the optical axis. Accommodative lenses can vary the focal distance by movement of the lens along the optical axis, for example, movement of single fixed focus lenses in the eye, as disclosed in, for example, US2019053893 and WO2006NL50050 (EP1871299), or, alternatively, movement of multiple lenses along the optical axis, as disclosed in, for example, US2018221139 and US2013013060 (CA2849167, US2002138140). Such lens movements can be driven by the ciliary muscle, generally via the remains, the rim, of the capsular bag, as in US2019053893, or, alternatively, such movement can be driven by the iris, as in, for example, WO2019027845, ES2650563 and US2008215146, or, alternatively, such movement can be driven by the zonulae which connect the capsular bag to the ciliary mass of the eye, as in, for example, US2018353288.
    Alternatively, a single multifocal lens, for example, a lens with a single cubic free-form surface or, alternatively, a lens with a bifocal or multifocal optical surface, can be moved in a direction perpendicular to the optical axis, as in US201010624.
    Also, translation of the focus of a lens along the optical axis can be achieved by a change of lens shape, a increase of central radial thickness of the lens, along the optical axis, as in, for example, AU2014236688, US201562257087 and US2018256315, which discloses lenses in which an elastic container filled with a fluid comprises a variable lens, or, alternatively, as in US2018344453, US10004595, US2018271645, US2019015198 and US9744028 which disclose a change in shape of a uniform elastic lens and, alternatively, as in US2012000162 which discloses an elastic lens driven by fluid pressure of the vitreous of the eye. US2012310341, US2011153015 and DE112009001492 disclose any type of shape changing lenses which lenses are positioned at the sulcus plane, instead of inside the remains of the capsular bag of the eye with such change of shape driven directly by the ciliary mass, or, alternatively, the zonulae system of the eye, or, alternatively, by the iris, or, alternatively, by the sclera, for example by the tip of the accommodative connected to the sclera of the eye.
    In addition, variable optics can be provided by two optical elements with each element comprising at least one free-form optical surface with such a shape that the combination of these shapes provides a variable lens of which the optical power depends on the relative position of the elements in a direction perpendicular to the optical axis, as in, for example, EP1720489, with the optical elements connected by, for example, a mechanical connector, as in NL2015644, or by glueing, or, by repolymerization by monomers from which the lens material also originates.
    Such lenses can provide a non-linear variation on optical power in response to a linear change in the mutual position of the optical elements, as in, for example, NL2012133,
    with the said free-form optical surfaces distributed over any number of surfaces of the optical elements, as in NL2012420. Intraocular lenses comprising such free-form variable optics and their application are known from, for example, but not restricted hereto from, referring to such intraocular lenses and applications: WO2019022608 disclosing free-form surfaces of, for example, different Zernike orders, which algorithms can also be expressed by, for example, NURBS or spline algorithms; US2012323320 discloses such mechanically adjustable lenses and US2017312133 discloses such laser adjustable lenses; NL2015538 and US2014336757 disclose haptics for the sulcus plane; NL2015616 discloses irrigation channels to reduce increase in intraocular pressure; US2016030162 discloses an electricity generator driven by such lens; WO
    2009051477 discloses piggy back, thin lens elements added to main lens elements to correct for residual optical errors; US2014074233 and US9744028 disclose partly anchoring of such lenses in the remains of the capsular bag; US2012257278 and EP1932492 disclose principles of variable correction of any combination of variable aberrations; WO2014058316 discloses alternative shapes for the elastics haptics of such lenses; NL210980 and EP2765952 disclose customized optics of such lenses; NL2009596 discloses mechanical additions to such lens to protect the posterior surface of the iris of the eye.
    Note that translation of the focus of a lens along the optical axis can be a parallel mutual shift of optical elements as used as the main example of variable lenses in this document, but also a rotation of at least one element as in the rotation of optical elements comprising at least two chiral optical surfaces in a direction perpendicular to the optical axis, WO2014058315 and ES2667277, or, alternatively, a combination of wedging and rotation of at least two complex free-form surfaces, for example adapted cubic optical surfaces, as in, for example, US2012323321. All the references cited in this document are considered part of this document as well as other documents refreed to therein.
    The present invention This document discloses a novel method to adjust an accommodating intraocular lens construction, also: ‘lens construction’, for properties of the ciliary mass of the eye with the lens construction including at least one variable lens component to provide variable optical power to the eye and including at least one haptic component to provide positioning of the lens construction inside the eye and to transfer of movement from the ciliary mass of the eye to at least one component of the variable lens. The method is provides adjustment of at least one property of at least one component of the lens construction with the rate of adjustment depending on the rate of least one property of the ciliary mass. For example, the method can provide adjustment of steepness, meaning: the rate of increase in variable optical power of the variable lens per the rate of contraction of the ciliary muscle, of variable optical power of the variable lens such that the rate of steepness corresponds to the rate of measured amplitude of contraction of the ciliary mass. Such method can provide a constant desired rate of accommodation, for example, a gradual 0-3D accommodation, or any other accommodative range providing the wearer of the lens a spectacle free life, with the rate of accommodation being independent of the amplitude of the individual ciliary mass during the accommodative process. Alternatively, the method can provide adjustment of the rate of linearity of the response of variable optical power of the variable lens such that the rate of linearity corresponds to the degree of measured amplitude of contraction of the ciliary mass. For example, a non-linear response can provide a non-linear increase in accommodative response of the lens to a linear rate of ciliary muscle contraction. Alternatively, the method can provide adjustment of the elastic property of the transfer haptic of lens construction such that the degree of elasticity corresponds to the degree of measured muscular power of the ciliary mass because individual ciliary masses of different eyes contract with different forces.
    The amplitude of contraction can be measured, preoperatively and postoperatively, by for example dynamic optical coherence tomography, OCT, or, alternatively, by dynamic ultrasonography. So, the method can include at least one preoperative measurement, or, alternatively, at least one postoperative measurement, or, alternatively, method can include any combination of at least one preoperative and at least one postoperative measurement with all measurements followed by and at least one corresponding adjustment, customization, of the lens construction.
    Note that the adjustment can be carried out, preoperatively, during the manufacturing of the accommodative lens, say, in the lens factory, or. alternatively, can be carried out postoperatively, in the eye, by, for example, an optical laser treatment of the lens, as disclosed by, for example, in the website http://www.perfectlens.com/ and in, for example, ES2625682, which method can adjust, customize, optical and mechanical properties of intraocular lenses postoperatively, meaning: adjustment, customization, of the lens construction after the implant in the eye, of the lens construction once inside the eye.
    So, the method provides an adjusted, customized, accommodative intraocular lens construction comprising multiple components including at least one variable lens to provide variable optical power to the eye, and, at least one combination of at least one anchoring haptic to provide positioning of the variable lens inside the eye, and, at least one transfer haptic to provide transfer of movement of the ciliary mass of the eye to at least one component of the variable lens with lens construction comprising at least one component of which at least one property is adapted to provide adjustment, customization, of the lens construction according to measurement of at least one property of the ciliary mass.
    The lens construction can comprises, for example, at least one variable lens component comprising a combination of at least two optical elements comprising a combination of at least two complementary free-form optical surfaces with each optical element comprising at least one such free-form optical surface with the combination adapted to provide a lens of variable defocus power which power depends on the degree of mutual translation of the optical elements in a direction perpendicular to the optical axis of the eye. Alternatively, the lens construction can comprise, for example, at least one variable lens component comprising at least one elastic optical component adapted to provide variable defocus power which power depends on the degree of change of radial shape, the central thickness, of the elastic optical component.
    Alternatively, the lens construction can comprise at least one variable lens component comprising any combination of variable lens components.
    权利要求:
    Claims (12)
    [1]
    A method of adjusting an accommodating intraocular lens structure for properties of the ciliary mass of the eye having the lens structure, comprising at least one variable lens component adapted to provide variable optical power to the eye, and at least comprises a haptic component adapted to provide a positioning of the lens structure within the eye and a transitional movement of the ciliary mass of the eye to at least one component of the variable lens, characterized in that the method comprises an adjustment, or adjustment, provided of at least one property of at least one component of the lens construction, the degree of adjustment being dependent on the degree of at least one property of the ciliary mass of the eye, and in particular being dependent on the volume or the force of the ciliary mass.
    [2]
    A method according to claim 1, characterized in that the method provides for adjustment of the steepness of the variable optical power of the variable lens so that the degree of steepness corresponds to the degree of the measured amplitude of contraction of the ciliary mass.
    [3]
    A method according to claim 1, characterized in that the method is adapted to provide adjustment of the degree of linearity regarding the response of the variable optical power of the variable lens, so that the degree of linearity corresponds to the degree of the measured amplitude of contraction of the ciliary mass.
    [4]
    A method according to claim 1, characterized in that the method is adapted to provide adjustment of the elastic property of the haptic transfer of the lens structure, so that the degree of elasticity corresponds to the degree of the measured muscle power of the ciliary mass.
    [5]
    Method according to claim 2 or 3, characterized in that the amplitude of contraction is measured by dynamic optical coherence tomography.
    [6]
    Method according to claim 2 or 3, characterized in that the amplitude of contraction is measured by dynamic ultrasonography.
    [7]
    Method according to any combination of claims 1-6, characterized in that the method comprises at least one pre-operative measurement and at least one associated adjustment of the lens construction.
    [8]
    Method according to any combination of claims 1-6, characterized in that the method comprises at least one post-operative measurement and at least one associated adjustment of the lens construction.
    [9]
    Method according to any combination of claims 1-6, characterized in that the method comprises any combination of at least one pre-operative measurement and at least one post-operative measurement, and at least one associated adjustment of the lens construction.
    [10]
    The biased accommodative intraocular lens structure according to the method of claims 1-6, wherein the structure comprises multiple components including at least one variable lens to provide variable optical power to the eye, and at least one combination of at least one haptic anchor to provide a to provide positioning of the variable lens within the eye, and at least one haptic transfer to provide transitional movement of the ciliary mass of the eye to at least one component of the variable lens, characterized in that the lens structure comprises at least one component at least one property of which has been adjusted or set, based on a measurement of at least one property of the ciliary mass.
    [11]
    The lens assembly of claim 10, characterized in that the lens assembly comprises at least one variable power lens comprising a combination of at least two optical elements comprising a combination of at least two complementary optical surfaces of arbitrary shape, each optical element comprises at least one such optical surface of arbitrary shape, the combination being adapted to provide a lens with variable defocusing power depending on the degree of mutual displacement of the optical elements in a direction perpendicular to the optical axis of the eye .
    [12]
    The lens structure of claim 10, characterized in that the lens structure comprises at least one variable power lens, which comprises at least one elastic optical component adapted to provide a variable defocus power, the power depending on the degree of change of radial shape of the elastic optical component.
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    申请号 | 申请日 | 专利标题
    NL2025158|2020-03-18|
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